Project outline

We will build upon the evidence-based HATICE Internet platform that we have developed in the FP-7 funded HATICE project ( This platform helps people to improve their risk factors for cardiovascular disease and dementia, such as hypertension, high cholesterol, diabetes mellitus, unhealthy diet, smoking and physical inactivity using an interactive self-management strategy.

We will adapt this platform to:
1) be used as a mobile Health application;
2) focus specifically on the prevention of cognitive decline and dementia
3) be socio-culturally appropriate for the use in the UK and China and allow for flexible adaptation for populations with other socio-cultural backgrounds

The following three phases will be followed.

PRODEMOS partners are from all over Europe and China

Project phases

Phase-1 Crossing Cultural barriers and adaptation

In the first phase of PRODEMOS, we will take multiple steps to gather key information for the optimal adjustment and implementation of the mHealth platform. We will specifically focus on crossing cultural barriers for dementia prevention by using qualitative research methods. This will take place in two settings:

  1. A population with low socio-economic status in a high income country (Brighton, UK)
  2. A population in a middle income setting (Greater Beijing, China)

A purposive sample of potential participants in both settings will participate in semi-structured interviews to explore cultural, socio-economic and educational barriers and facilitators of dementia prevention for the following two main topics:

  1. The general concept of self-management of risk factors to prevent dementia.
  2. Views on the acceptability and usability of the mHealth platform prototype for sustained lifestyle behaviour change.

As we will focus on the implementation of an intervention, involving the users and developers of the intervention is essential in the design and conduct phases of the project.

Preliminary outcomes of the qualitative research will iteratively feed into the cycles to adapt the mHealth platform to create a final platform that is ready to be tested in the implementation trial. AMC will educate and train CMU researchers for the execution of the qualitative research in the local setting.

Phase-2 Adaption – from eHealth to mHealth

In a second phase, which runs partly in parallel to phase 1, we will adapt the eHealth platform (HATICE), which is based on current evidence, for risk factor management to an mHealth platform for dementia prevention. The mHealth platform will be adjusted and specifically tailored to the target population using the information from phase 1 of the project. The platform will be adjusted to be culturally appropriate, but also to fit the existing health care structures in both settings.

This phase will finish with a pilot study among a random sample of end-users from the target population in the two settings, to finalize the application prior to the implementation trial in phase 3.

Phase-3 Implementation trial, health economics and dissemination

In the third and final phase, an individually randomised implementation trial will be performed to study the implementation of the adapted mHealth platform in socio-economically deprived individuals in the United Kingdom and in the general population of China. Rather than controlling for conditions or removing influencing factors, real-world conditions will be followed as much as possible. In parallel, health economic aspects, including a cost-effectiveness analysis, will be addressed to inform policymakers on the future course of dementia prevention strategies. Finally we aim to prepare for upscaling and wide implementation beyond the duration of this project